Prof. Kyunghee Chun
Dept. of Biochemistry and
Obesity, Ubiquitin, deubiquitinating, ML323, USP1 inhibitor
Current development stage
Preclinical, Animal experiment
Ubiquitin specific peptidase1 (USP1) is one of the family of deubiquitinating enzyme (DUB) which is mostly known to regulate DNA-damage pathway in regard to cancer. Interestingly, USP1 was highly expressed in differentiated adipocytes, and when its expression levels were reduced by siRNA, adipocyte differentiation was retarded and lipid accumulation was remarkably reduced. This phenomenon was also observed by using ML323 which is a USP1 specific inhibitor. ML323 treatment on differentiating adipocytes inhibited the differentiation of adipocytes and lipid accumlation was also inhibited by regulating the adipogenesis related genes such as FASN, PPARgamma, C/EBPalpha or FABP4. Therefore, USP1 specific inhibitor ML323 might be a potential drug in preventing or treating obesity.