Promising Technologies

A Composition for Preventing or Treating Metabolic Disorders Comprising a Tat Peptide Variant as an Active Ingredient

  • Inventor
    Prof. Hur Man-Wook
  • Category
    Metabolic Disorder, Obesity
  • Keywords
    Metabolic Disorders, Tat Peptide, Obesity
  • Current development stage
  • Patent Status
    KR patent application
  • Brief Description
    The inventors attempted to develop a medication that is easily synthesized and that has a low risk of side effects despite long-term administration, while having treatment activity for metabolic disorders including obesity, diabetes, hyperlipidemia, fatty liver, and insulin resistance syndrome. Among the TAT peptides (72a.a) derived from the HIV-1 virus that show antiobesity activity, the CDK9 binding site and cyclin T1 binding site, which play a crucial role in fat reduction, are identified; then, when 11 amino acids between them are substituted with aliphatic amino carboxylic acids while preserving their domains, the antiobesity activity of the TAT peptide is maintained while the water solubility and yield are substantially increased. Upon discovering this, the present technology was completed. The present invention serves as a medication for the prevention and treatment of metabolic disorders.

    Obesity is a metabolic disorder caused by an imbalance between energy intake and energy consumption, resultin gin hypertrophy and hyperplasia of in-vivo fat cells. Obesity is the most common nutritional disorder in Western societies, and the frequency of obesity is also increasing in South Korea due to increased food availability and the Westernization of lifestyles. As such, the obesity rate in South Korea has increased steadily every year, and by 2030 it is projected number of South Koreans who are extremely obese will double. Furthermore, the socioeconomic loss due to obesity was found to be 9.2 trillion KRW as of 2015, which was double the cost noted ten years prior, and this trend is forecasted to continue to accelerate due to factors such as the aging of society. The present invention’s composition maintains the fat reduction effect of the natural TAT peptide while increasing water solubility and synthetic yield; as such, it can serve as a useful treatment for metabolic disorders. Consequently, this invention has the potential to contribute significantly to solving the current situation in which the obese population is increasing, as mentioned above.
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